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Ibrutinib deacryloylpiperidine (IBT4A) 是 Ibrutinib 的一種雜質。Ibrutinib 是一種不可逆的選擇性 Btk 抑制劑，IC50 為 0.5 nM。
伊布替尼中間體N-2性質：
沸點: 577.4±50.0°C(Predicted)
密度:1.380±0.06g/cm3(Predicted)
酸度系數(pKa): 10.40±0.30(Predicted)
[1]. Somana Siva Prasad, et al. A QUALITY BY DESIGN APPROACH FOR DEVELOPMENT OF SIMPLE AND ROBUST REVERSED PHASE STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF IBRUTINIB AND ITS IMPURITIES.
[2]. Honigberg LA, et al. The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80.
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